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American Society of Hematology (ASH)
ASH 2017 – ITP
ASH 2017 – ITP
Avatrombopag Superior to Placebo for the Treatment of Chronic ITP
ASH 2017 – ITP
Results of this randomized, placebo-controlled phase 3 trial showed that avatrombopag was superior to placebo in terms of the cumulative number of weeks with a platelet response, platelet response at day 8, and durability of platelet response in patients with refractory chronic immune thrombocytopenia (ITP).
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No Link between Long-Term Eltrombopag Treatment and Incidence of Cataracts in Adult Patients with Chronic ITP During EXTEND
ASH 2017 – ITP
The current study found no clear evidence linking eltrombopag treatment and risk for cataract development/progression in patients with chronic immune thrombocytopenia (ITP).
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Eltrombopag Treatment Improved Platelet Counts in Patients with Persistent or Chronic ITP
ASH 2017 – ITP
The current post-hoc subanalysis of a phase 4 open-label study concluded that the effects on platelet counts after eltrombopag treatment for >2 years was comparable between the persistent immune thrombocytopenia (ITP) and the chronic ITP cohorts, with similar safety profiles.
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Fostamatinib-Treated Patients with Persistent/Chronic ITP Maintained Long-Term Responses
ASH 2017 – ITP
These study results showed that heavily pretreated patients with persistent/chronic immune thrombocytopenia (ITP) who achieved a stable response with fostamatinib therapy maintained their responses for ≥12 months.
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Subcutaneous Romiplostim Increased Platelet Response in Children with ITP
ASH 2017 – ITP
This open-label study reported that the majority of children with immune thrombocytopenia (ITP) who received open-label romiplostim for ≥6 months achieved a platelet response, with median platelet counts >50 × 10
9
/L from week 12 onward and no new safety signals observed during the study period.
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