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American Society of Clinical Oncology (ASCO)
ASCO 2025 - Small Cell Lung Cancer
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ASCO 2025 - Small Cell Lung Cancer
Phase 3 DeLLphi-304: Primary Analysis of Tarlatamab Versus Chemotherapy as Second-Line Treatment for Patients With SCLC
ASCO 2025 - Small Cell Lung Cancer
The DeLLphi-304 trial shows tarlatamab significantly improves survival with a manageable adverse-event profile over chemotherapy, establishing a new standard of care for patients with small cell lung cancer (SCLC) after platinum-based chemotherapy.
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A Randomized, Phase 2 Trial Evaluating Atezolizumab Maintenance Therapy Following Chemoradiotherapy in LS-SCLC
ASCO 2025 - Small Cell Lung Cancer
A randomized, phase 2 study found atezolizumab maintenance after chemoradiotherapy in limited-stage small cell lung cancer (LS-SCLC) did not improve survival outcomes and caused additional toxicities.
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IMforte Phase 3 Study: Lurbinectedin Plus Atezolizumab Improves Survival in Extensive-Stage Small Cell Lung Cancer
ASCO 2025 - Small Cell Lung Cancer
The IMforte study showed clinically meaningful improvements in progression-free survival and overall survival with lurbinectedin plus atezolizumab compared with atezolizumab alone in patients with extensive-stage small cell lung cancer.
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Promising Phase 2 Results for ZG006, a Trispecific T-Cell Engager, in Advanced Small Cell Lung Cancer
ASCO 2025 - Small Cell Lung Cancer
ZG006 demonstrated promising efficacy and a tolerable safety profile in patients with advanced small cell lung cancer, supporting further evaluation in the ongoing phase 2 study.
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