Articles

Among patients with HER2-positive metastatic breast cancer previously treated with trastuzumab, pertuzumab, and trastuzumab emtansine, the addition of tucatinib to trastuzumab and capecitabine showed clinically meaningful improvements in efficacy independent of hormone receptor status. Read More ›

In this final overall survival analysis of ExteNET, there were fewer deaths with neratinib despite not reaching statistical significance and greater overall survival with neratinib in subgroups. Read More ›

The healthcare resource utilization of brain metastases is significantly higher among patients with HER2-positive metastatic breast cancer compared with patients without brain metastases, emphasizing the critical need for effective systemic therapies that improve outcomes and decrease the burden of disease. Read More ›

Geriatric patients with HER2-positive advanced breast cancer demonstrated shorter chemotherapy durations, poorer overall survival, and increased rates of adverse events, highlighting the need for prospective studies to improve outcomes. Read More ›

The use of circulating tumor cells to monitor HER2 status may help to identify patients who could benefit from a modified treatment approach with anti-HER2 therapy, through supplementation or switching to another therapy as necessary based on receptor switch. Read More ›

ARX788-211 is a phase 2/3 randomized, multicenter, open-label trial comparing ARX788 with lapatinib and capecitabine in patients with HER2-positive, locally advanced, or metastatic breast cancer. Read More ›

To evaluate the use of tucatinib with T-DM1 for unresectable locally advanced or metastatic HER2-positive breast cancer, enrollment for the HER2CLIMB-02 trial is ongoing in the United States and planned internationally. Read More ›

Patients with HER2-positive metastatic breast cancer treated with ≥2 lines of HER2-directed therapy had better outcomes in the neratinib plus capecitabine arm compared with the lapatinib plus capecitabine arm irrespective of the baseline status of CNS metastases. Read More ›