Articles

To evaluate the use of tucatinib with T-DM1 for unresectable locally advanced or metastatic HER2-positive breast cancer, enrollment for the HER2CLIMB-02 trial is ongoing in the United States and planned internationally. Read More ›

Patients with HER2-positive metastatic breast cancer treated with ≥2 lines of HER2-directed therapy had better outcomes in the neratinib plus capecitabine arm compared with the lapatinib plus capecitabine arm irrespective of the baseline status of CNS metastases. Read More ›

Among patients with relapsed/refractory acute myeloid leukemia (R/R AML), patient-specific doses of iodine-131-apamistamab resulted in consistent engraftment following allogeneic hematopoietic stem-cell transplantation. Read More ›

No new safety signals associated with gilteritinib were found in a study comparing gilteritinib + azacitidine with azacitidine alone in patients with newly diagnosed, FLT3-mutated AML. A composite response rate of 67% was found among patients in the safety cohort receiving gilteritinib + azacitidine. Read More ›

Compared with pomalidomide and dexamethasone (Pd) alone, daratumumab + Pd reduced the risk for disease progression and death without additional safety signals for patients with RRMM who had received ≥1 prior lines of therapy, including lenalidomide and a proteasome inhibitor. Read More ›

In pretreated, high-risk patients with relapsed or refractory chronic lymphocytic leukemia (CLL), treatment with lisocabtagene maraleucel (liso-cel) resulted in a high rate of undetectable minimal residual disease. Responses to treatment with liso-cel were rapid and durable, without late or delayed adverse events of concern. Read More ›

The noncovalent BTK inhibitor LOXO-305 demonstrated promising efficacy in patients with previously treated chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). LOXO-305 was well-tolerated and active in patients following multiple prior lines of therapy, including patients with and without BTK C481 mutations. Read More ›

CPX-351 plus 7 days of venetoclax was tolerable and demonstrated encouraging activity in patients with relapsed/refractory acute myeloid leukemia. Read More ›

Treatment with CD19-CAR T-cells in patients with chronic lymphocytic leukemia (CLL) and disease transformation was found to be safe and demonstrates a high rate of complete remission. Read More ›

An escalated 21-day CC-486 (oral azacitidine) dosing regimen was well-tolerated and restored remission in approximately 25% of patients with acute myeloid leukemia (AML) who relapsed with 5% to 15% blasts on-study in the QUAZAR AML-001 trial. Read More ›