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SERENA-6 Phase 3 Trial: Camizestrant Plus CDK4/6 Inhibitor for ctDNA-Guided Treatment of ESR1 Mutations in HR-Positive, HER2-Negative Advanced Breast Cancer
By
Hope S. Rugo, MD, FASCO
ASCO 2025 - Breast Cancer Faculty Commentary
The SERENA-6 trial reveals camizestrant's potential to improve outcomes in hormone receptor (HR)-positive, HER2-negative breast cancer by utilizing circulating tumor DNA (ctDNA)-guided therapy towards ESR1 mutations before disease progression.
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Videos
Patient-Reported Outcomes of Imlunestrant in EMBER-3 Trial for ER-Positive, HER2-Negative Advanced Breast Cancer
By
Hope S. Rugo, MD, FASCO
ASCO 2025 - Breast Cancer Faculty Commentary
Patient-reported outcomes from EMBER-3 demonstrate that imlunestrant improves global health status/quality of life and physical function in patients with ESR1 mutations in estrogen receptor (ER)-positive, HER2-negative advanced breast cancer.
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Videos
Understanding the Current Paradigm and New Approaches in the Care of Patients With Endometrial Cancer
By
Paula Anastasia, MN, RN, AOCN
ONS 2025 - Endometrial Cancer
In this fourth installment, Paula reviews relevant data for immunotherapies currently FDA approved for patients with advanced endometrial cancer.
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Videos
Advancing Nursing Science Through Data Science
By
Paula Anastasia, MN, RN, AOCN
ONS 2025 - Endometrial Cancer
In this third installment, Paula will discuss the importance and relevance of data science in advancing the field of nursing.
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Videos
Treatment of Patients With Advanced Endometrial Carcinoma
By
Paula Anastasia, MN, RN, AOCN
ONS 2025 - Endometrial Cancer
In this first installment, Paula will discuss recent data of immunotherapy in patients with advanced endometrial cancer and highlight nursing considerations to help manage side effects.
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Videos
Importance of Health Equity in Gynecologic Cancers
By
Paula Anastasia, MN, RN, AOCN
ONS 2025 - Endometrial Cancer
In this second installment, Paula will discuss a health equity study investigating the association of neighborhood socioeconomic deprivation in patients with gynecologic cancers.
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Videos
SIM0270 Monotherapy and in Combination With Everolimus Shows Promise in Advanced Breast Cancer Treatment
By
Erica L. Mayer, MD, MPH
SABCS 2024 - Breast Cancer Faculty Commentary
Dr Erica Mayer explains the results of a study utilizing the novel SERD SIM0270, as monotherapy and in combination, in the treatment of patients with estrogen receptor–positive, HER2-negative advanced breast cancer.
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Videos
Study Demonstrates Elacestrant Benefit Is Maintained Regardless of ESR1 Mutation Levels
By
Erica L. Mayer, MD, MPH
SABCS 2024 - Breast Cancer Faculty Commentary
Dr Erica Mayer discusses an analysis of the EMERALD study, which explores the effects of variant allele frequencies on outcomes for patients with advanced breast cancer being treated with elacestrant.
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Videos
Real-World Outcomes of Elacestrant in Patients With ESR1-Mutated Breast Cancer
By
Erica L. Mayer, MD, MPH
SABCS 2024 - Breast Cancer Faculty Commentary
Dr Erica Mayer comments on real-world outcomes for elacestrant derived from the GuardantINFORM database, and describes which patients elacestrant therapy may be best for.
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Videos
Imlunestrant Shows Promise for Patients With ESR1-Mutated Advanced Breast Cancer
By
Erica L. Mayer, MD, MPH
SABCS 2024 - Breast Cancer Faculty Commentary
Dr Erica Mayer discusses the positive results of the EMBER-3 trial, and the impact that imlunestrant will have on the treatment of patients with advanced breast cancer
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