Articles

Aumolertinib, a novel EGFR inhibitor, shows prolonged clinical benefit in a randomized comparison with gefitinib as first-line therapy in advanced non–small-cell lung cancer (NSCLC) with EGFR exon 19 del or L858R mutation. Read More ›

Overall survival is longer for patients with advanced non–small-cell lung cancer who received atezolizumab and had immune-related adverse events versus patients who received atezolizumab and did not have immune-related adverse events. Read More ›

Therapeutic outcomes based on plasma-based comprehensive genomic profiling are comparable to published tissue-based targeted therapy clinical outcomes in non–small-cell lung cancer (NSCLC). Read More ›

Chemotherapy plus immunotherapy (IO) may improve efficacy outcomes over IO alone in most patients with advanced non–small-cell lung cancer (NSCLC) and programmed death ligand 1 (PD-L1) scores between 1% and 49%. Read More ›

Survival outcomes are not worse for patients with endothelial ovarian cancer treated with neoadjuvant chemotherapy if cytoreduction surgery is delayed beyond 3 cycles of treatment. Read More ›

Niraparib improved progression-free survival when used as maintenance therapy in patients with newly diagnosed, advanced ovarian cancer with BRCA wild-type tumors, regardless of homologous recombination status. Read More ›

Early preoperative PET-CT examination in patients with advanced-stage ovarian cancer treated with neoadjuvant chemotherapy may be a useful prognostic tool. Read More ›

Inhibition of AKT or DNA-PK in combination with cisplatin results in reduced cell growth and proliferation. The use of AKT and DNA-PK inhibitors may improve overall survival for patients with platinum-resistant high-grade serous ovarian cancer. Read More ›

Pathways were identified that are crucial in the mechanism of PARP inhibitor resistance in patients with ovarian cancer. Key signaling kinases were identified as therapeutic targets and folate receptor 1 was identified as a potential biomarker for treatment response. Read More ›

Insulin-like growth factor binding protein-2 (IGFBP2) was demonstrated to be a potential biomarker for the diagnosis of ovarian cancer. The assessment of preoperative serum IGFBP2 levels in patients with adnexal mass may have the potential to differentiate between malignant and benign ovarian tumors. Read More ›