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Alpelisib Overcomes Resistance to CDK4/6 Inhibitors in HR-Positive/HER2-Negative Advanced Breast Cancer Patients
ASCO 2021 – Breast Cancer
Alpelisib may overcome resistance to CDK4/6 inhibitors in HR-positive/HER2-negative advanced breast cancer patients with shorter exposure to prior CDK4/6 inhibitor treatment.
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Demographic and Clinical Factors Among Women with Breast Cancer Create a Gap Between Referrals and Completion of Genetic Counseling and Testing
ASCO 2021 – Breast Cancer
Lack of genetic counseling referrals in women diagnosed with breast cancer contribute to a gap between the need for and completion of genetic testing, reducing access to more personalized therapies for these patients.
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Effect of Alpelisib on Progression-Free Survival in Breast Cancer Patients with PIK3CA Mutations in the Real-World Setting
ASCO 2021 – Breast Cancer
Alpelisib activity improves real-world progression-free survival in breast cancer patients with
PIK3CA
mutations when used in combination with fulvestrant compared with fulvestrant alone.
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Trends in Male Breast Cancer Survival Rates from 1988 to 2017
ASCO 2021 – Breast Cancer
Research indicates no significant improvement in breast cancer–specific survival in male breast cancer in the past 30 years.
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Association of Poor Prognostic Understanding and Discordance Between Older Patients with Advanced Cancer and Oncologists
ASCO 2021 – Breast Cancer
Prognostic understanding may be associated with hospitalization or hospice use depending on how patients were queried about their prognosis and whether oncologists’ estimates were considered.
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Implementation of Patient-Reported Remote Symptom Monitoring System in Patients Receiving Intravenous Cancer Therapy
ASCO 2021 – Breast Cancer
Electronic patient-reported outcome remote monitoring of patients receiving parenteral cancer therapy in routine clinical care is feasible. Office intervention may reduce the need for emergency and inpatient services.
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Cost-Effectiveness of Adjuvant Osimertinib in Resected EGFR-Mutated NSCLC Patients
ASCO 2021 – Lung Cancer
Modeling of the ADAURA trial data showed that 3 years of adjuvant osimertinib was more cost-effective than placebo in
EGFR
-mutated non–small-cell lung cancer (NSCLC).
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Utilization of Multigene Assays in Patients with NSCLC
ASCO 2021 – Lung Cancer
The LC-SCRUM-Asia project analysis indicated that utilization of rapid multigene assays in patients with advanced non–small-cell lung cancer (NSCLC) was associated with short turnaround times and high success rates compared with a targeted assay.
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Prior Authorization Tool Impacts Provider Adherence to Clinical Guidelines and Cost-Savings
ASCO 2021 – Lung Cancer
Provider adherence to National Comprehensive Cancer Network recommendations and implementation of an automated regimen-level prior authorization is associated with lower cost and more efficient oncology care in patients with non–small-cell lung cancer.
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Repeat Molecular Profiling Detects Actionable Genetic Alterations in Patients with Progressive Lung Cancer
ASCO 2021 – Lung Cancer
The majority of progressing stage IV non–small-cell lung cancer patients with development of resistance to targeted therapies benefit from repeat molecular profiling to detect actionable resistance mechanisms and facilitate clinical trial enrollment.
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