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Phase 2 Results From the ELEVATE Study: Elacestrant Combined With Everolimus or Abemaciclib in ER-Positive/HER2-Negative Locally Advanced or Metastatic Breast Cancer
SABCS 2025 - ER+/HER2- Breast Cancer
The ELEVATE study highlights elacestrant-based combinations as a promising all-oral treatment strategy to overcome resistance and improve outcomes in estrogen receptor–positive/HER2-negative metastatic breast cancer.
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Radiotherapy in Patients Undergoing Breast-Conserving Surgery With or Without Axillary Sentinel Lymph Node Biopsy: Secondary Analysis of the INSEMA Trial
SABCS 2025 - ER+/HER2- Breast Cancer
The INSEMA trial reveals how axillary surgery and radiotherapy techniques influence dose distribution and regional nodal irradiation in patients with early breast cancer undergoing breast-conserving surgery.
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Secondary Analysis of the INSEMA Trial: Axillary Surgery in Breast Cancer Patients With 1 to 3 Sentinel Node Macrometastases Undergoing Breast-Conserving Therapy
SABCS 2025 - ER+/HER2- Breast Cancer
The INSEMA trial explores the safety and benefits of sentinel lymph node biopsy omission versus completion axillary lymph node dissection in patients with early breast cancer undergoing breast-conserving surgery.
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LORETTA (JCOG1505) Trial: A Single-Arm Study of Tamoxifen Alone Without Surgery for Low-Risk, ER-Positive/HER2-Negative DCIS of the Breast
SABCS 2025 - ER+/HER2- Breast Cancer
The LORETTA trial evaluates tamoxifen monotherapy as a potential nonsurgical option for carefully selected patients with low-risk, estrogen receptor–positive/HER2-negative ductal carcinoma in situ.
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Primary Findings From the HR-Positive/HER2-Negative Cohort of TBCRC-053 (P-RAD): Evaluating Preoperative Radiation Doses Combined With Pembrolizumab and Chemotherapy in Node-Positive, HER2-Negative Breast Cancer
SABCS 2025 - ER+/HER2- Breast Cancer
Discover how combining preoperative radiation with immunotherapy is revolutionizing treatment for high-risk, HR-positive/HER2-negative breast cancer in a groundbreaking clinical trial.
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Impact of Preoperative Breast MRI Staging on Local Regional Recurrence in Early-Stage Breast Cancer: Results From Alliance A011104/ACRIN 6694
SABCS 2025 - ER+/HER2- Breast Cancer
New research reveals that preoperative breast MRI may not improve outcomes for early-stage breast cancer patients, challenging its routine use in surgical planning.
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Patient Perspectives on Intramuscular Versus Oral Endocrine Therapy in Metastatic Breast Cancer
SABCS 2025 - ER+/HER2- Breast Cancer
New insights reveal patient preferences for oral endocrine therapy over intramuscular options in metastatic breast cancer, emphasizing the need for personalized treatment decisions.
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Real-World Analysis of ESR1 Mutation Testing and Positivity Rates in ER-Positive/HER2-Negative Metastatic Breast Cancer
SABCS 2025 - ER+/HER2- Breast Cancer
New research highlights critical gaps in
ESR1
mutation testing for estrogen receptor (ER)-positive/HER2-negative metastatic breast cancer, emphasizing the need for increased use of blood-based circulating tumor DNA methods to improve treatment outcomes.
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The ADELA Study: Elacestrant Plus Everolimus Versus Elacestrant Plus Placebo in ER-Positive/HER2-Negative Advanced Breast Cancer With ESR1 Mutations After Progression on Endocrine Therapy and CDK4/6 Inhibitors
SABCS 2025 - ER+/HER2- Breast Cancer
The ADELA trial investigates the potential of combining elacestrant with everolimus to overcome resistance and improve outcomes in
ESR1
-mutated, estrogen receptor (ER)-positive/HER2-negative advanced breast cancer after progression on endocrine therapy and CDK4/6 inhibitors.
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New Strategies in Breast Cancer Treatment: Overcoming Resistance to CDK Inhibitors
SABCS 2025 - ER+/HER2- Breast Cancer
Discover the latest breakthroughs in breast cancer treatment, as innovative strategies to overcome resistance to CDK inhibitors are explored, and new therapeutic possibilities are unlocked.
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