Articles

The phase 2 AIM study examined the efficacy and safety of the combination of ibrutinib and venetoclax in relapsed/refractory mantle-cell lymphoma (MCL). Read More ›

A phase 1 study explores a combination of a novel Bruton’s tyrosine kinase (BTK) inhibitor, DTRMWXHS-12 (DTRM-12), with everolimus and pomalidomide in patients with chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin lymphoma. Read More ›

The multicenter, randomized, double-blind, placebo-controlled phase 3 PERSPECTIVE study compares the progression-free survival outcomes of ibrutinib with rituximab versus placebo with rituximab in patients with treatment-naïve (TN) follicular lymphoma (FL). Read More ›

This phase 1 trial evaluates the safety and efficacy of the triplet combination of TGR-1202, ublituximab, and ibrutinib in patients with B-cell malignancies. Read More ›

Chimeric antigen receptor T-cell therapy is an immunotherapeutic approach that has yielded favorable outcomes in various hematologic malignancies. Educating oncology nurses on how to recognize serious adverse events, such as cytokine release syndrome (CRS), is critical for early intervention and reducing CRS-related deaths. Read More ›

Breast cancer is the second leading cause of cancer-related deaths in women in the United States. Despite the increase in survival with trastuzumab in the adjuvant setting, up to 26% of patients with early-stage HER2+ breast cancer experience disease recurrence within 5 to 8 years. The interim analysis after 5 years of follow-up in the ExteNET trial is presented.

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Adherence to prescribed therapy is pivotal in cancer treatment. To ensure that patients receive the full benefit of their prescribed therapy, nurses and nurse practitioners play a critical role in identifying adverse events and implementing effective interventions that balance efficacy and tolerability.

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Nivolumab is an immune checkpoint inhibitor approved for the treatment of patients with relapsed or refractory classical Hodgkin lymphoma. This immunotherapeutic agent is associated with immune-related adverse events that require prompt identification for successful management and resolution.

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The use of monoclonal antibodies in the treatment of cancer is rapidly evolving. These immunomodulating agents are associated with an increased incidence of hypersensitivity reaction. Prompt identification and effective management is essential for optimal patient care.

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Blinatumomab is the only single-agent therapy approved for patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia. This bispecific antibody induces complete remission, as well as serious adverse events, including central nervous system toxicities and cytokine release syndrome. Oncology nurses play a critical role in early identification and intervention of these toxicities. Read More ›

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